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LHF-535

This product is for research use only, not for human use. We do not sell to patients.

LHF-535
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$450To Be Confirmed
250mg$850To Be Confirmed
500mg$1275To Be Confirmed
email: [email protected]        [email protected]

Cat #: V32815 CAS #: 1450929-77-7 Purity ≥ 99%

Description: LHF-535 (LHF535) is a novel and potent antiviral agent with EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.

References: Dongcheng Dai, et al. Antiviral drugs for treatment of arenavirus infection. WO2013123215A2.

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Molecular Weight (MW)412.52
Molecular FormulaC27H28N2O2
CAS No.1450929-77-7
SMILES CodeCC(O)(C1=CC=C(/C=C\C2=CC=C3N(C4=CC=C(OC(C)C)C=C4)C=NC3=C2)C=C1)C
SynonymsLHF 535; LHF-535; LHF535
ProtocolIn VitroLHF-535 is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein (GP). LHF-535 exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses. LHF-535 inhibits Lassa GP-pseudotyped lentivirus with an IC50 of 0.1-0.3 nM.
In VivoLHF-535 (3, 10 or 30 mg/kg; orally; daily; 14 days) protectes mice from a lethal challenge with Tacaribe virus and dramatically reduces viral titers in plasma, spleen, and liver.
Animal modelIFN-α/β and-γ receptor-deficient AG129 mice
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4241 mL12.1206 mL24.2412 mL48.4825 mL
5mM0.4848 mL2.4241 mL4.8482 mL9.6965 mL
10mM0.2424 mL1.2121 mL2.4241 mL4.8482 mL
20mM0.1212 mL0.6060 mL1.2121 mL2.4241 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.