LETERMOVIR
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $850 | Check With Us |
| 500mg | $1350 | Check With Us |
| 1g | $2025 | Check With Us |
: Cat #: V3910 CAS #: 917389-32-3 Purity ≥ 98%
Description: Letermovir (formerly MK-8828; MK8828; AIC-246; AIC246; trade name: Prevymis) is a potent anti-cytomegalovirus (CMV) / antiviral drug approved on 11/8/2017 by FDA to prevent infection after bone marrow transplant.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 572.56 |
|---|---|
| Molecular Formula | C29H28F4N4O4 |
| CAS No. | 917389-32-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=C(O)C[C@@H]1N(C2=CC(C(F)(F)F)=CC=C2OC)C(N3CCN(C4=CC=CC(OC)=C4)CC3)=NC5=C1C=CC=C5F |
| Synonyms | AIC-246; MK-8828; AIC 246; MK 8828; AIC246; MK8828 |
| Protocol | In Vitro | AIC246 has consistent antiviral efficacy, and there is remarkable selectivity of AIC246 for human cytomegaloviruses. |
|---|---|---|
| In Vivo | Letermovir (10-100 mg/kg/day, p.o.) leads to a dose-dependent reduction of the HCMV titer in transplanted cells compared to that of the placebo-treated control group using the mouse xenograft model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7465 mL | 8.7327 mL | 17.4654 mL | 34.9308 mL |
| 5mM | 0.3493 mL | 1.7465 mL | 3.4931 mL | 6.9862 mL |
| 10mM | 0.1747 mL | 0.8733 mL | 1.7465 mL | 3.4931 mL |
| 20mM | 0.0873 mL | 0.4366 mL | 0.8733 mL | 1.7465 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.