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Ac-CoA Synthase Inhibitor1

This product is for research use only, not for human use. We do not sell to patients.

Ac-CoA Synthase Inhibitor1
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$950Check With Us
500mg$1550Check With Us
1g$2325Check With Us
email: [email protected]        [email protected]

Cat #: V25182 CAS #: 508186-14-9 Purity ≥ 99%

Description: Ac-CoA Synthase Inhibitor1, also known as ACSS2 Inhibitor or Ac-CoA Synthase Inhibitor I, is a Ac-CoA Synthase Inhibitor with antiviral effects.

References: Sarah A Comerford, et al. Acetate dependence of tumors. Cell. 2014 Dec 18;159(7):1591-602.

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Molecular Weight (MW)410.51
Molecular FormulaC20H18N4O2S2
CAS No.508186-14-9
SMILES CodeO=C(NCCOC)NC1=CC=C2N=C(C3=CC=CS3)C(C4=CC=CS4)=NC2=C1
SynonymsMDK-6149; MDK 6149; MDK6149; ACSS2 Inhibitor; Ac-CoA Synthase Inhibitor I;
ProtocolIn VitroAc-CoA Synthase Inhibitor1 inhibits cellular [14C]acetate uptake into both lipids and histones with an IC50 of 5 µM. Ac-CoA Synthase Inhibitor1 inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 of 6.8 µM. Ac-CoA Synthase Inhibitor1 inhibits HepG2 utilization of [14C]acetate for histone acetylation with IC50 of 5.5 µM.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4360 mL12.1800 mL24.3599 mL48.7199 mL
5mM0.4872 mL2.4360 mL4.8720 mL9.7440 mL
10mM0.2436 mL1.2180 mL2.4360 mL4.8720 mL
20mM0.1218 mL0.6090 mL1.2180 mL2.4360 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.