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Bemnifosbuvir hemisulfate (RG-6422; AT-527)

This product is for research use only, not for human use. We do not sell to patients.

Bemnifosbuvir hemisulfate (RG-6422; AT-527)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1250Check With Us
200mg$1875Check With Us
500mg$3160Check With Us
email: [email protected]        [email protected]

Cat #: V41681 CAS #: 2241337-84-6 Purity ≥ 99%

Description: Bemnifosbuvir hemisulfate (RG-6422; AT-527), the hemisulfate salt of AT-511, is a guanosine nucleotide prodrug and orally bioactive HCV viral replication inhibitor.

References: Steven S Good, et al. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus. PLoS One. 2020 Jan 8;15(1):e0227104.

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Molecular Weight (MW)630.58
Molecular FormulaC24H33FN7O7P.1/2H2O4S
CAS No.2241337-84-6
SMILES CodeC[C@@H](C(OC(C)C)=O)N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@H](N3C=NC4=C(NC)N=C(N)N=C34)[C@](C)(F)[C@@H]2O)=O.C[C@@H](C(OC(C)C)=O)N[P@@](OC5=CC=CC=C5)(OC[C@H]6O[C@@H](N7C=NC8=C(NC)N=C(N)N=C78)[C@](C)(F)[C@@H]6O)=O.O=S(O)(O)=O
SynonymsBemnifosbuvir hemisulfate; AT-511 hemisulfate; AT511; AT-511; AT 527; AT-527; AT527; RG 6422; RG-6422; RG6422;
ProtocolIn VitroBemnifosbuvir hemisulfate has pan-genotypic antiviral activities that inhibits HCV genotype 1a (HCV GT1a), HCV GT1b, HCV GT2a, HCV GT3a, HCV GT4a, and HCV GT5a replication with EC50 values of 12.8 nM, 12.5 nM, 9.2 nM, 10.3 nM, 14.7 nM, and 28.5 nM, respectively.
In VivoWhen given orally to rats (500 mg/kg) and monkeys (30 mg/kg, 100 mg/kg or 300 mg/kg), Bemnifosbuvir hemisulfate preferentially delivers high levels of AT-9010 in the liver in vivo.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.5858 mL7.9292 mL15.8584 mL31.7168 mL
5mM0.3172 mL1.5858 mL3.1717 mL6.3434 mL
10mM0.1586 mL0.7929 mL1.5858 mL3.1717 mL
20mM0.0793 mL0.3965 mL0.7929 mL1.5858 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.