Paquinimod

This product is for research use only, not for human use. We do not sell to patients.

Paquinimod
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$650Check With Us
250mg$1250Check With Us
500mg$1875Check With Us

Cat #: V17488 CAS #: 248282-01-1 Purity ≥ 99%

Description: Paquinimod (ABR‑215757; ABR215757) is a novel and potent S100A9 inhibitor that can prevent S100A9 binding to TLR-4 (Toll like receptor-4).

References: Schelbergen RF, et al. Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Ann Rheum Dis. 2015 Dec;74(12):2254-8.

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Molecular Weight (MW)350.41
Molecular FormulaC21H22N2O3
CAS No.248282-01-1
SMILES Code O=C(C1=C(O)C2=C(N(C)C1=O)C=CC=C2CC)N(CC)C3=CC=CC=C3
SynonymsABR‑215757; ABR 215757; ABR215757; Paquinim
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.8538 mL14.2690 mL28.5380 mL57.0760 mL
5mM0.5708 mL2.8538 mL5.7076 mL11.4152 mL
10mM0.2854 mL1.4269 mL2.8538 mL5.7076 mL
20mM0.1427 mL0.7134 mL1.4269 mL2.8538 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.