VV116 | CAS 2647442-33-7

VV116

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$4500	Check With Us
200mg	$6750	Check With Us
500mg	$11390	Check With Us

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Cat #: V4354 CAS #: 2647442-33-7 Purity ≥ 99%

Description: VV-116 (also known as VV116, JT-001) is a novel, potent and orally administered anti-SARS-CoV-2 nucleoside drug candidate (IC50 = 0.67±0.24 μM) acting as a viral RNA-dependent RNA polymerase (RdRp) inhibitor and is under investigation for COVID-19 treatment in China.

References: Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

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Molecular Weight (MW)	502.5461
Molecular Formula	C24H30DN5O7
CAS No.	2647442-33-7
Synonyms	VV116; VV-116; JT-001; JT001; JT 001; VV 116;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9899 mL	9.9493 mL	19.8987 mL	39.7973 mL
5mM	0.3980 mL	1.9899 mL	3.9797 mL	7.9595 mL
10mM	0.1990 mL	0.9949 mL	1.9899 mL	3.9797 mL
20mM	0.0995 mL	0.4975 mL	0.9949 mL	1.9899 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.