AWZ1066S
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1200 | Check With Us |
| 250mg | $1900 | Check With Us |
| 500mg | $2850 | Check With Us |
: Cat #: V31482 CAS #: 2239272-16-1 Purity ≥ 99%
Description: AWZ1066S is a novel, potent and highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis, with an EC50 of 2.5 nM in cell assay.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 404.39 |
|---|---|
| Molecular Formula | C19H19F3N6O |
| CAS No. | 2239272-16-1 |
| SMILES Code | FC(C1=NC=CC=C1CNC2=C(C=CC=N3)C3=NC(N4[C@@H](C)COCC4)=N2)(F)F |
| Synonyms | AWZ106S; AWZ-1066; AWZ 1066; AWZ1066S; AWZ-1066S; AWZ 1066S; |
| Protocol | In Vitro | AWZ1066S has a weak CYP2C9 inhibitory activity with an IC50 value of 9.7 μM and has a weak CYP3A4 induced activity with an IC50 value of 37 uM, but does not show any time-dependent inhibition across five majorhuman CYP450 isoforms (CYP1A, CYP2C9, CYP2C19, CYP2D6, CYP3A). |
|---|---|---|
| In Vivo | AWZ1066S has anti-Wolbachia activity with EC50 value of 121 nM. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4729 mL | 12.3643 mL | 24.7286 mL | 49.4572 mL |
| 5mM | 0.4946 mL | 2.4729 mL | 4.9457 mL | 9.8914 mL |
| 10mM | 0.2473 mL | 1.2364 mL | 2.4729 mL | 4.9457 mL |
| 20mM | 0.1236 mL | 0.6182 mL | 1.2364 mL | 2.4729 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.