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SQ109 (NSC 722041)

This product is for research use only, not for human use. We do not sell to patients.

SQ109 (NSC 722041)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1390To Be Confirmed
200mg$2085To Be Confirmed
500mg$3510To Be Confirmed
email: [email protected]        [email protected]

Cat #: V5129 CAS #: 502487-67-4 Purity ≥ 98%

Description: SQ109 (NSC-722041) is an antituberculosis drug which is currently in advanced clinical trials for the treatment of drug-susceptible and drug-resistant tuberculosis, it is a novel, potent and selective inhibitor of the trypomastigote form of the parasite with IC50 for cell killing of 50±8 nM.

References: Veiga-Santos P, et al. SQ109, a new drug lead for Chagas disease. Antimicrob Agents Chemother. 2015 Apr;59(4):1950-61

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Molecular Weight (MW)330.55
Molecular FormulaC22H38N2
CAS No.502487-67-4
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeC/C(CC/C=C(C)\C)=C\CNCCNC1[C@H]2C[C@@H]3C[C@H](C2)CC1C3
SynonymsSQ109; SQ-109; SQ 109; NSC722041; NSC 722041; NSC-722041;
ProtocolIn VitroSQ109 also inhibits extracellular epimastigotes (IC50, 4.6±1 μM) and the clinically relevant intracellular amastigotes (IC50, ~0.5 to 1 μM), with a selectivity index of ~10 to 20. SQ109 has little effect (EC50, ~80 μM) in a red blood cell hemolysis assay. Besides, SQ109 causes major ultrastructural changes in all three life cycle forms, as observed by light microscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM).
In VivoOral administration of SQ109 (0.1-25 mg/kg per day) to the mice for 28 days results in dose-dependent reductions of mycobacterial load in both spleen and lung comparable to that of EMB administered at 100 mg/kg per day, but is less potent than isoniazid (INH) at 25 mg/kg per day. Pharmacokinetic profiles of SQ109 in mice following a single administration showed its Cmax as 1038 (intravenous (i.v.)) and 135 ng/mL (p.o.), with an oral Tmax of 0.31 h. The elimination t1/2 of SQ109 is 3.5 (i.v.) and 5.2 h (p.o.). The oral bioavailability is 4%.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0253 mL15.1263 mL30.2526 mL60.5052 mL
5mM0.6051 mL3.0253 mL6.0505 mL12.1010 mL
10mM0.3025 mL1.5126 mL3.0253 mL6.0505 mL
20mM0.1513 mL0.7563 mL1.5126 mL3.0253 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.