Eflornithine HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$450	To Be Confirmed
1g	$750	To Be Confirmed
5g	$1890	To Be Confirmed

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Cat #: V3609 CAS #: 68278-23-9 Purity ≥ 98%

Description: Eflornithine hydrochloride is a potent, specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is used as a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women. Facial hirsutism is a cosmetic concern for women and can lead to significant anxiety and lack of self-esteem. Eflornithine cream is indicated for the treatment of facial hirsutism. However, limited success rate and overall patient's satisfaction, even with a long-term and high-frequency application, leave room for improvement.

References: Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	218.63
Molecular Formula	C₆H₁₃ClF₂N₂O₂
CAS No.	68278-23-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Synonyms	FMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride; MDL-71782 hydrochloride; RMI-71782 hydrochloride; α-difluoromethylornithine hydrochloride; MDL 71782 hydrochloride; RMI 71782 hydrochloride; α-difluoromethylornithine hydrochloride

Protocol	In Vivo	Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Related Biological Data

Digital photographs of C57BL/6 mouse dorsal skin with and without treatment with the Vaniqa eflornithine cream (13.9%) for up to 36 days.

In vitro permeation of eflornithine hydrochloride in a solution through a mouse skin area where the hair was trimmed (without microneedle), or trimmed and then treated with microneedles (with microneedle). Data shown are mean ± S.D. (n = 3). Drug Deliv. 2016 Jun;23(5):1495-501.

Representative micrographic pictures of skin samples after anti-BrdU staining (A) or H&E staining (B). Scale bar = 2 mm. Drug Deliv. 2016 Jun;23(5):1495-501.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.5739 mL	22.8697 mL	45.7394 mL	91.4788 mL
5mM	0.9148 mL	4.5739 mL	9.1479 mL	18.2958 mL
10mM	0.4574 mL	2.2870 mL	4.5739 mL	9.1479 mL
20mM	0.2287 mL	1.1435 mL	2.2870 mL	4.5739 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.