Fluensulfone
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1000 | Check With Us |
| 500mg | $1700 | Check With Us |
| 1g | $2550 | Check With Us |
: Cat #: V20479 CAS #: 318290-98-1 Purity ≥ 99%
Description: Fluensulfone is a novel and potent nematicide.
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| Molecular Weight (MW) | 291.70 |
|---|---|
| Molecular Formula | C7H5ClF3NO2S2 |
| CAS No. | 318290-98-1 |
| SMILES Code | O=S(CC/C(F)=C(F)\F)(C1=NC=C(Cl)S1)=O |
| Synonyms | Fluensulfone |
| Protocol | In Vitro | Lower concentrations of Fluensulfone delay development: 100 μM Fluensulfone causes a slight delay as at 66 h fewer worms have reached the adult stage whilst at 300 μM no worms reach the adult stage at 66 h and some fail to reach L4. Adult hermaphrodites lay fewer eggs in the presence of 1 mM Fluensulfone. Fluensulfone is also found to reduce the viability of eggs. After 3 h incubation with 100 μM to 1 mM Fluensulfone the thrashing rate is significantly inhibited, with maximal inhibition occurring with 1 mM. After 1 h both 300 μM and 1 mM Fluensulfone cause a significant and reversible inhibition of pharyngeal pumping relative to the vehicle control. Fluensulfone (500 μM) inhibits the frequency of body bends in one day old adult hermaphrodites off food after 2 h exposure. |
|---|---|---|
| In Vivo | In an in vivo investigation, female mice are treated with Fluensulfone (or isoniazid as a positive control) for 3 and 7 days. Quantification of the cell proliferation by manual counting of BrdU-positive and BrdU-negative cells in the bronchiolar epithelium reveals an approximately fourfold increase of cell proliferation upon treatment with Fluensulfone and the positive control isoniazid compare with control. Increased cell proliferation is observed at 3 days but have reverted to the control level at day 7. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4282 mL | 17.1409 mL | 34.2818 mL | 68.5636 mL |
| 5mM | 0.6856 mL | 3.4282 mL | 6.8564 mL | 13.7127 mL |
| 10mM | 0.3428 mL | 1.7141 mL | 3.4282 mL | 6.8564 mL |
| 20mM | 0.1714 mL | 0.8570 mL | 1.7141 mL | 3.4282 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.