GRP 60367 | CAS 1309241-34-6

GRP 60367

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1150	Check With Us
500mg	$1750	Check With Us
1g	$2625	Check With Us

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Cat #: V2214 CAS #: 1309241-34-6 Purity ≥ 99%

Description: GRP 60367 is a novel,potent and selective rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 inhibits entry of a subset of RABV strains. Resistance profiling of the chemotype revealed hot spots in conserved hydrophobic positions of the RABV G protein fusion loop that were confirmed in transient cell-to-cell fusion assays. Transfer of RABV G genes with signature resistance mutations into a recombinant VSV backbone resulted in the recovery of replication-competent virions with low susceptibility to the inhibitor.

References: [1]. Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94(13):e00321-20.

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Molecular Weight (MW)	353.466
Molecular Formula	C21H27N3O2
CAS No.	1309241-34-6
SMILES Code	O=C(N1CCC(NCCOC2=CC(C)=CC=C2C)CC1)C3=CC=NC=C3
Synonyms	GRP-60367; GRP60367; GRP 60367;

Protocol	In Vitro	GRP-60367 inhibits entry of a subset of RABV strains. GRP-60367 shows specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC50s ranging from 2 to 52 nM on different host cell lines.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.8291 mL	14.1456 mL	28.2913 mL	56.5825 mL
5mM	0.5658 mL	2.8291 mL	5.6583 mL	11.3165 mL
10mM	0.2829 mL	1.4146 mL	2.8291 mL	5.6583 mL
20mM	0.1415 mL	0.7073 mL	1.4146 mL	2.8291 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.