Cefiderocol
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $4500 | Check With Us |
| 200mg | $6750 | Check With Us |
| 500mg | $11390 | Check With Us |
: Cat #: V17834 CAS #: 1225208-94-5 Purity ≥ 99%
Description: Cefiderocol (S-649266; GSK-2696266D; S-649266D; trade name Fetroja) is an injectable siderophore cephalosporin antibiotic that has a catechol moiety on the 3-position of the side chain and was under clinical trials by Shionogi.
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| Molecular Weight (MW) | 752.21 |
|---|---|
| Molecular Formula | C30H34ClN7O10S2 |
| CAS No. | 1225208-94-5 |
| SMILES Code | OC(C(O)=C1Cl)=CC=C1C(NCC[N+]2(CCCC2)CC3=C(C([O-])=O)N4C([C@H]([C@]4(SC3)[H])NC(/C(C5=CSC(N)=N5)=N\OC(C(O)=O)(C)C)=O)=O)=O |
| Synonyms | S 649266D; S649266D; Cefiderocol; Fetroja; S-649266; S 649266; S649266; GSK2696266D; GSK-2696266D; GSK 2696266D; S-649266D; |
| Protocol | In Vitro | Cefiderocol (S-649266), a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including carbapenem-resistant strains of Enterobacteriaceae and nonfermenting bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. Cefiderocol has affinity mainly for PBP3 of Enterobacteriaceae and nonfermenting bacteria similar to that of GR20263. A deficiency of the iron transporter PiuA in P. aeruginosa or both CirA and Fiu in Escherichia coli can cause 16-fold increases in cefiderocol MICs, suggesting that these iron transporters contribute to the permeation of cefiderocol across the outer membrane. The deficiency of OmpK35/36 in Klebsiella pneumoniae and the overproduction of efflux pump MexA-MexB-OprM in P. aeruginosa show no significant impact on the activity of cefiderocol. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.3294 mL | 6.6471 mL | 13.2942 mL | 26.5883 mL |
| 5mM | 0.2659 mL | 1.3294 mL | 2.6588 mL | 5.3177 mL |
| 10mM | 0.1329 mL | 0.6647 mL | 1.3294 mL | 2.6588 mL |
| 20mM | 0.0665 mL | 0.3324 mL | 0.6647 mL | 1.3294 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.