tylosin | CAS 1401-69-0

tylosin

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$290	Check With Us
1g	$470	Check With Us
5g	$1180	Check With Us

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Cat #: V3559 CAS #: 1401-69-0 Purity ≥ 98%

Description: Tylosin (also known as Fradizine; Tylocine; Tylosin A) is a broad spectrum antibiotic and a bacteriostatic against Gram-positive organisms and a limited range of Gram-negative organisms. Tylosin is found naturally as a fermentation product of Streptomyces fradiae. It is a macrolide antibiotic. Tylosin is used in veterinary medicine to treat bacterial infections in a wide range of species and has a high margin of safety. It has also been used as a growth promotant in some species, and as a treatment for colitis in companion animals.

References: Mingfu Liu, et al. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23): 14658-14663.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	916.112
Molecular Formula	C46H77NO17
CAS No.	1401-69-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(=C\[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)\C
Synonyms	Fradizine; Tylocine; Tylosin; Tylosin A; Tilosina; Tylan; Vubityl 200

Protocol	In Vitro	Tylosin exerts antibacterial effects by binding to 23S rRNA of the bacterial ribosomal 50S subunit .
	In Vivo	Tylosin (10-500 mg/kg; s.c.) generally suppresses the elevated TNF-α and IL-1β levels and increases the IL-10 levels in the Lipopolysaccharide (LPS) -treated animals.
	Animal model	Balb/C mice (2-3 months old, 20-25 g)
	Dosages	10 mg/kg, 100 mg/kg, 500 mg/kg
	Administration	Subcutaneous injection

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.0916 mL	5.4578 mL	10.9157 mL	21.8314 mL
5mM	0.2183 mL	1.0916 mL	2.1831 mL	4.3663 mL
10mM	0.1092 mL	0.5458 mL	1.0916 mL	2.1831 mL
20mM	0.0546 mL	0.2729 mL	0.5458 mL	1.0916 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.