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Moxifloxacin (BAY12-8039)

This product is for research use only, not for human use. We do not sell to patients.

Moxifloxacin (BAY12-8039)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$150In Stock
5g$300In Stock
10g$450In Stock

Cat #: V32679 CAS #: 151096-09-2 Purity ≥ 98%

Description: Moxifloxacin (Avelox, Avalox, Avelon, Vigamox, Moxeza; BAY12-8039; BAY12-8039; BAY 12-8039) is an orally bioactive, broad spectrum and 4th generation antibiotic agent of the fluoroquinolone class with high activity against both Gram positive and Gram negative bacteria.

References: Culley, C.M., et al., Moxifloxacin: clinical efficacy and safety. Am J Health Syst Pharm, 2001. 58(5): p. 379-88.

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Molecular Weight (MW)401.43
Molecular FormulaC21H24FN3O4
CAS No.151096-09-2
SMILES CodeO=C(C1=CN(C2CC2)C3=C(C=C(F)C(N(C4)C[C@]5([H])[C@@]4([H])CCCN5)=C3OC)C1=O)O
SynonymsAvelox, Avalox, Avelon, Vigamox,  BAY12-8039; BAY 12-8039; BAY12-8039; Moxeza;
ProtocolIn VitroThe in vitro activities of Moxifloxacin and Amoxicillin are compared by time-kill curve and inhibition of intracellular growth experiments by using a model of bone marrow-derived mouse macrophages infected by L. monocytogenes EGDe. Moxifloxacin acts much more rapidly, beginning to exert its effects in the first 3 h and achieving complete broth sterilization within 24 h of incubation. Moxifloxacin appears to have a protective effect against macrophage lysis, as many cells are still viable after 24 h of incubation.
In VivoMoxifloxacin (12 mg/kg; intravenous injection; once-three times per day; for 7 days; white male Wistar rats) treatment every 8 hours is accompanied by longer survival. Tissue cultures 30 hours after bacterial challenge shows considerably less bacterial overgrowth in the spleens and lungs of moxifloxacin-treated than in salinetreated animals and without being toxic.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4911 mL12.4555 mL24.9109 mL49.8219 mL
5mM0.4982 mL2.4911 mL4.9822 mL9.9644 mL
10mM0.2491 mL1.2455 mL2.4911 mL4.9822 mL
20mM0.1246 mL0.6228 mL1.2455 mL2.4911 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.