Lanopepden | CAS 1152107-25-9

Lanopepden

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$4875	To Be Confirmed
200mg	$7300	To Be Confirmed
1μg	$12300	To Be Confirmed

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Cat #: V3525 CAS #: 1152107-25-9 Purity ≥ 98%

Description: Lanopepden (formerly known as GSK 1322322 and GSK-322) is a novel, potent and selective peptide deformylase inhibitor with activity against Staphylococcus aureus strains with MICs of 1 and 1 mg/L for ATCC 29213 and ATCC 25923 strain, respectively. It has good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. Lanopepden had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. Lanopepden represents a valuable alternative therapy for the treatment of infectious diseases caused by drug-resistant pathogens.

References: Peyrusson F, et al. Cellular pharmacokinetics and intracellular activity of the novel peptide deformylase inhibitor GSK1322322 against Staphylococcus aureus laboratory and clinical strains with various resistance phenotypes: studies with human THP-1 monoc

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Physicochemical and Storage Information
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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	479.56
Molecular Formula	C22H34FN7O4
CAS No.	1152107-25-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=CN(C[C@@H](CC1CCCC1)C(NNC2=NC(C)=NC(N3C[C@@]4([H])COCCN4CC3)=C2F)=O)O
Synonyms	GSK-322; GSK322; GSK 322; GSK-1322322; GSK1322322; GSK 1322322; GSK-1322322B; GSK-1322322J; GSK 1322322B

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0852 mL	10.4262 mL	20.8524 mL	41.7049 mL
5mM	0.4170 mL	2.0852 mL	4.1705 mL	8.3410 mL
10mM	0.2085 mL	1.0426 mL	2.0852 mL	4.1705 mL
20mM	0.1043 mL	0.5213 mL	1.0426 mL	2.0852 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.