This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 2g | $250 | Check With Us |
| 10g | $750 | Check With Us |
| 20g | $1125 | Check With Us |
: Cat #: V1917 CAS #: 64-73-3 Purity ≥ 98%
Description: Demeclocycline HCl (also known as demeclocycline hydrochloride; trade names: Detravis; Ledermycin), a protein translation inhibitor and potential calpain inhibitor, is a potent tetracycline antibiotic that inhibits the protein synthesis in bacteria, it is used for the treatment of bacterial infections. Demeclocycline is a semisynthetic tetracycline antibiotic which was derived from a strain of Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis.
References: [1]. Cherrill DA, et al. Demeclocycline treatment in the syndrome of inappropriate antidiuretic hormone secretion. Ann Intern Med. 1975 Nov;83(5):654-6
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| Molecular Weight (MW) | 501.31 |
|---|---|
| Molecular Formula | C21H21ClN2O8 .HCl |
| CAS No. | 64-73-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (199.5 mM)r |
| Water: 26 mg/mL (51.9 mM)r | |
| Ethanol: <1 mg/mL | |
| SMILES Code | O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])[C@H](O)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4Cl)N.[H]Cl |
| Synonyms | Detravis; Ledermycin; Declostatin; Ledermycin; Bioterciclin; Deganol; Deteclo; Declomycin; Demeclociclina; Demeclocyclinum; DMCTC; Meciclin; Mexocine; Clortetrin |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9948 mL | 9.9739 mL | 19.9477 mL | 39.8955 mL |
| 5mM | 0.3990 mL | 1.9948 mL | 3.9895 mL | 7.9791 mL |
| 10mM | 0.1995 mL | 0.9974 mL | 1.9948 mL | 3.9895 mL |
| 20mM | 0.0997 mL | 0.4987 mL | 0.9974 mL | 1.9948 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.