CILASTATIN
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $250 | Check With Us |
| 500mg | $380 | Check With Us |
| 1g | $570 | Check With Us |
: Cat #: V4386 CAS #: 82009-34-5 Purity ≥ 98%
Description: Cilastatin (formerly MK791; MK-0791; Recarbrio) is a renal dehydropeptidase inhibitor and a leukotriene D4 dipeptidase inhibitor with nephroprotective effects.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 358.45 |
|---|---|
| Molecular Formula | C16H26N2O5S |
| CAS No. | 82009-34-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | [C@H]1(C(C1)(C)C)C(=O)N/C(=C\CCCCSC[C@@H](C(=O)O)N)C(=O)O |
| Synonyms | MK-0791; MK 0791; MK 0791; MK 791; MK0791; Cilastatina; Cilastatine; Cilastatinum; Cilastatin Monosodium Salt ;Cilastatin Sodium; M K-791; MK0791; MK791; Monosodium Salt, Cilastatin; Salt, Cilastatin Monosodium. |
| Protocol | In Vitro | Cilastatin (200 μg/mL; 24 hours; RPTECs) treatment protects against Vancomycin-induced proximal tubule apoptosis and increases cell viability, without compromising the antimicrobial effect of Vancomycin. |
|---|---|---|
| In Vivo | In a mouse model (female mice, strain CD-1, 20 g) of systemic infection, Imipenem plus Cilastatin can protect mice from S. aureus, E. coli, and P. aeruginosa infection. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7898 mL | 13.9489 mL | 27.8979 mL | 55.7958 mL |
| 5mM | 0.5580 mL | 2.7898 mL | 5.5796 mL | 11.1592 mL |
| 10mM | 0.2790 mL | 1.3949 mL | 2.7898 mL | 5.5796 mL |
| 20mM | 0.1395 mL | 0.6974 mL | 1.3949 mL | 2.7898 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.