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| Size | Price | Stock |
|---|---|---|
| 500mg | $395 | In Stock |
| 1g | $550 | In Stock |
| 5g | $1400 | In Stock |
: Cat #: V8312 CAS #: 1192491-61-4 Purity ≥ 98%
Description: Avibactam (NXL-104; NXL104; Avycaz) is a covalent/reversible non-β-lactam β-lactamase inhibitor approved for use in combination with ceftazidime by the FDA on February 25, 2015 for treating bacterial infections, including those caused by multi-drug resistant gram-negative bacterial pathogens.
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| Molecular Weight (MW) | 287.23 |
|---|---|
| Molecular Formula | C7H10N3NaO6S |
| CAS No. | 1192491-61-4 |
| SMILES Code | O=C1N(OS(=O)(O[Na])=O)[C@H]2CN1[C@H](C(N)=O)CC2 |
| Synonyms | NXL104; NXL-104; NXL 104; Avibactam; Avibactam sodium |
| Protocol | In Vitro | Avibactam (NXL104) is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases. Avibactam inactivates most important β-lactamases except metallo types and Acinetobacter OXA carbapenemases[2]. |
|---|---|---|
| In Vivo | Avibactam sodium displays a slow return of activity with an off-rate of 0.045±0.022 min-1, which converts to a residence time half-life (tt1/2) of 16±8 min. The measured off-rate for Avibactam suggests that slow deacylation through hydrolysis or reversibility is occurring, and it is in contrast to previously reported extremely long t1/2 values of >1 or >7 d for Avibactam inhibition of TEM-1[1]. Avibactam is a new promising β-lactamase inhibitor, to overcome resistance caused by β-lactamases. Mice are infected with ca.106 CFU of Pseudomonas aeruginosa intramuscularly into the thigh or intranasally to cause pneumonia and are given 8 different (single) subcutaneous doses of Ceftazidime and Avibactam in various combined concentrations, ranging from 1 to 128 mg/kg of body weight in 2-fold increases. The mean estimated half-life in plasma of Ceftazidime in the terminal phase is 0.28 h (SD, 0.02 h), and that of Avibactam is 0.24 h (SD, 0.04 h). Volumes of distribution are 0.80 liters/kg (SD, 0.14 liters/kg) and 1.18 liters/kg (SD, 0.34 liters/kg), respectively[3]. |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4815 mL | 17.4077 mL | 34.8153 mL | 69.6306 mL |
| 5mM | 0.6963 mL | 3.4815 mL | 6.9631 mL | 13.9261 mL |
| 10mM | 0.3482 mL | 1.7408 mL | 3.4815 mL | 6.9631 mL |
| 20mM | 0.1741 mL | 0.8704 mL | 1.7408 mL | 3.4815 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.