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Nacubactam

This product is for research use only, not for human use. We do not sell to patients.

Nacubactam
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1250Check With Us
200mg$1875Check With Us
500mg$3165Check With Us
email: [email protected]        [email protected]

Cat #: V26192 CAS #: 1452458-86-4 Purity ≥ 99%

Description: Nacubactam (OP-0595; RG-6080, FPI-1459) is a novel, non-β-lactam and potent beta-lactamase inhibitor with antibacterial activity against class A and class C β-lactamases.

References: Monogue ML, et al. In Vivo Efficacy of Meropenem with a Novel Non-β-Lactam-β-Lactamase Inhibitor, Nacubactam, against Gram-Negative Organisms Exhibiting Various Resistance Mechanisms in a Murine Complicated Urinary Tract Infection Model. Antimicrob Agents

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Molecular Weight (MW)324.31
Molecular FormulaC9H16N4O7S
CAS No.1452458-86-4
SMILES Code O=S(O)(ON1[C@]2([H])CC[C@@H](C(NOCCN)=O)[N@@](C2)C1=O)=O
SynonymsNacubactam; OP-0595; OP 0595; OP0595; FPI-1459; FPI 1459; FPI1459; RG-6080; RG 6080; RG6080;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0835 mL15.4173 mL30.8347 mL61.6694 mL
5mM0.6167 mL3.0835 mL6.1669 mL12.3339 mL
10mM0.3083 mL1.5417 mL3.0835 mL6.1669 mL
20mM0.1542 mL0.7709 mL1.5417 mL3.0835 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.