Erythromycin

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50g	$450	Check With Us
100g	$650	Check With Us
200g	$975	Check With Us

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Cat #: V20285 CAS #: 114-07-8 Purity ≥ 98%

Description: Erythromycin is a potent and broad-spectrum antibiotic belonging to a group of drugs called macrolide antibiotics, it is produced by actinomycete Streptomyces erythreus and is an inhibitor of protein translation and mammalian mRNA splicing.

References: Gribble MJ, et al. Erythromycin. Med Clin North Am. 1982 Jan;66(1):79-89.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	733.93
Molecular Formula	C37H67NO13
CAS No.	114-07-8
SMILES Code	C[C@@H]([C@@H]([C@H](C(O[C@@H]([C@@]([C@H](O)[C@@H](C)C1=O)(C)O)CC)=O)C)O[C@H]2C[C@]([C@@H](O)[C@H](C)O2)(OC)C)[C@H]([C@](C)(O)C[C@H]1C)O[C@H](O[C@@H](C[C@@H]3N(C)C)C)[C@@H]3O
Synonyms	Eryc-125; Eryc-250; Erythromycin; Emycin; HSDB 3074; HSDB-3074; HSDB3074;

Protocol	In Vitro	Erythromycin inhibits growth of P. falciparum with IC50 and IC90 values of 58.2 μM and 104.0 μM, respectively.
	In Vivo	Erythromycin (gastric intubation; 0.1-50 mg/kg; 30-120 days) decreases tumor growth and prolong the survival time of mice from dose of 5 mg/kg in mice.
	Animal model	Female ddY mice at the age of 6 weeks with EAC cells or CDF mice at the age of 6 weeks with P388 cells
	Dosages	0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg
	Administration	Gastric intubation; 30-120 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.3625 mL	6.8126 mL	13.6253 mL	27.2506 mL
5mM	0.2725 mL	1.3625 mL	2.7251 mL	5.4501 mL
10mM	0.1363 mL	0.6813 mL	1.3625 mL	2.7251 mL
20mM	0.0681 mL	0.3406 mL	0.6813 mL	1.3625 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.