Avibactam sodium hydrate (NXL 104 hydrate)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $700 | Check With Us |
| 2g | $1150 | Check With Us |
| 5g | $1940 | Check With Us |
: Cat #: V41090 CAS #: N/A Purity ≥ 99%
Description: Avibactam sodium hydrate (NXL104; NXL-104 hydrate; Avycaz), the sodium salt and hydrated form of avibactam, is a novel, potent, and covalent reversible non-β-lactam β-lactamase inhibitor with antibiotic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 305.24 |
|---|---|
| Molecular Formula | C7H12N3NaO7S |
| CAS No. | N/A |
| Synonyms | Avibactam; Avibactam sodium; Avycaz; NXL104 sodium hydrate; NXL-104; NXL 104; |
| Protocol | In Vitro | Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases. |
|---|---|---|
| In Vivo | Ceftazidime-Avibactam (0.375 mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2761 mL | 16.3806 mL | 32.7611 mL | 65.5222 mL |
| 5mM | 0.6552 mL | 3.2761 mL | 6.5522 mL | 13.1044 mL |
| 10mM | 0.3276 mL | 1.6381 mL | 3.2761 mL | 6.5522 mL |
| 20mM | 0.1638 mL | 0.8190 mL | 1.6381 mL | 3.2761 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.