Thiostrepton
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $550 | Check With Us |
| 5g | $990 | Check With Us |
| 10g | $1485 | Check With Us |
: Cat #: V9796 CAS #: 1393-48-2 Purity ≥ 98%
Description: Thiostrepton is thiazole-based cyclic peptide isolated from Streptomyces and is active against gram-positive bacteria.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 1664.89 |
|---|---|
| Molecular Formula | C72H85N19O18S5 |
| CAS No. | 1393-48-2 |
| SMILES Code | C=C(C(NC(C(N)=O)=C)=O)NC(C1=CSC(C2=NC(C3=CSC(C(C(C)OC(C4=CC(C(C)O)=C(C=CC(NC(C(NC(C)C(NC(C(NC(C)C5=O)=O)=C)=O)=O)C(C)CC)C6O)C6=N4)=O)N7)=N3)C(CC2)(N5)C8=NC(C(NC(C(N/C(C9=NC(C(NC(C(O)(C)C(C)O)C%10=NC(C7=O)=CS%10)=O)CS9)=C/C)=O)C(O)C)=O)=CS8)=N1)=O |
| Synonyms | Thiostrepton; NSC 170365; NSC-170365; NSC170365 |
| Protocol | In Vitro | Thiostrepton (0.01-1000 μM; 48 hours) suppresses cell viability in A2780 and HEC-1A. |
|---|---|---|
| In Vivo | Thiostrepton (i.p.; 17 mg/kg) reduces the tumorigenicity of Ewing's sarcoma (EWS) cells. Tumor volumes in control mice have increased ~6-fold from the initiation of treatment, while their Thiostrepton-treated counterparts increase only ~1.7-fold, exhibiting a ~3.5-fold reduction, relative to controls. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 0.6006 mL | 3.0032 mL | 6.0064 mL | 12.0128 mL |
| 5mM | 0.1201 mL | 0.6006 mL | 1.2013 mL | 2.4026 mL |
| 10mM | 0.0601 mL | 0.3003 mL | 0.6006 mL | 1.2013 mL |
| 20mM | 0.0300 mL | 0.1502 mL | 0.3003 mL | 0.6006 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.