Thiolutin | CAS 87-11-6

Thiolutin

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$2650	Check With Us
200mg	$3975	Check With Us
500mg	$6700	Check With Us

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Cat #: V11037 CAS #: 87-11-6 Purity ≥ 98%

Description: Thiolutin (formerly Acetopyrrothin and NSC-3927), is a potent and naturally occusinrg disulfide-containing antibiotic and anti-angiogenic agent isolated from Streptomyces, it acts as a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases, also inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36.

References: Lauinger L, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol. 2017 Jul;13(7):709-714.

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Molecular Weight (MW)	228.29
Molecular Formula	C8H8N2O2S2
CAS No.	87-11-6
SMILES Code	CN1C2=CSSC2=C(NC(C)=O)C1=O
Synonyms	Thiolutin; Acetopyrrothin; NSC 3927; NSC-3927; NSC3927

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.3804 mL	21.9020 mL	43.8039 mL	87.6079 mL
5mM	0.8761 mL	4.3804 mL	8.7608 mL	17.5216 mL
10mM	0.4380 mL	2.1902 mL	4.3804 mL	8.7608 mL
20mM	0.2190 mL	1.0951 mL	2.1902 mL	4.3804 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.