This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 250mg | $1280 | Check With Us |
| 500mg | $2050 | Check With Us |
| 1g | $3075 | Check With Us |
: Cat #: V2442 CAS #: 1041434-82-5 Purity ≥ 98%
Description: Peramivir Trihydrate (also known as BCX-1812, RWJ-270201, S-021812; trade name Rapivab) is a trihydrate form of the antiviral agent peramivir which is a transition-state analogue and a specific influenza viral neuraminidase inhibitor approved for the treatment of influenza. It inhibits with neuraminidase an IC50 of median 0.09 nM. Peramivir protects mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets. Peramivir combined with Oseltamivir perform better than suboptimal doses of each compound alone to treat influenza infections in mice. Peramivir (30 mg/kg) is effective in promoting the survival of mice infected with systemically replicating H5N1 virus.
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 382.45 |
|---|---|
| Molecular Formula | C15H28N4O4.3H2O |
| CAS No. | 1041434-82-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: <1 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | O=C([C@@H]1[C@@H](O)[C@@H]([C@@H](NC(C)=O)C(CC)CC)[C@H](NC(N)=N)C1)O.[H]O[H].[H]O[H].[H]O[H] |
| Synonyms | BCX-1812,RWJ-270201, S-021812; BCX1812; BCX 1812; RWJ 270201; RWJ270201; Peramivir. Brand name: Rapivab; Rapiacta and Peramiflu |
| Protocol | In Vitro | In vitro activity: N/A Kinase Assay: N/A Cell Assay: N/A |
|---|---|---|
| In Vivo | Peramivir protects mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets. Peramivir combined with Oseltamivir perform better than suboptimal doses of each compound alone to treat influenza infections in mice. Peramivir (30 mg/kg) is effective in promoting the survival of mice infected with systemically replicating H5N1 virus. Peramivir is 30% protective against H1N1 virus in mice at 0.5 mg/kg/d, but ineffective at lower doses when used as monotherapy. Peramivir combined with favipiravir increases the numbers of survivors by 10-50% when the 0.025 mg/kg/d, 0.05 mg/kg/d, and 0.1 mg/kg/d doses of Peramivir are combined with 20 mg/kg/d Favipiravir and when all doses of Peramivir are combined with 40 mg/kg/d Favipiravir. Peramivir combined with favipiravir results in an increase in lifespan, improved body weight and significant reductions in lung hemorrhage score and lung weight in H1N1 infected mice. Peramivir (1 mg/kg/d) combined with Rimantadine (5 mg/kg/d and 10 mg/kg/d) produces weight losses of 1.69 and 0.69, respectively, whereas the combination of 3.0 mg/kg/d Peramivir with 10 and 30 mg/kg/d Rimantadine does not show any weight loss in sub-lethal influenza A (H3N2) virus mouse model. | |
| Animal model | Mice |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6147 mL | 13.0736 mL | 26.1472 mL | 52.2944 mL |
| 5mM | 0.5229 mL | 2.6147 mL | 5.2294 mL | 10.4589 mL |
| 10mM | 0.2615 mL | 1.3074 mL | 2.6147 mL | 5.2294 mL |
| 20mM | 0.1307 mL | 0.6537 mL | 1.3074 mL | 2.6147 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.