Harringtonine
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
Size | Price | Stock |
---|---|---|
100mg | $750 | Check With Us |
250mg | $1250 | Check With Us |
500mg | $1875 | Check With Us |
Cat #: V20830 CAS #: 26833-85-2 Purity ≥ 98%
Description: Harringtonine is a natural Cephalotaxus alkaloid found in Cephalotaxuts.
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Molecular Weight (MW) | 531.59 |
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Molecular Formula | C28H37NO9 |
CAS No. | 26833-85-2 |
SMILES Code | O=C(O[C@@H]1C(OC)=C[C@]2(CCC3)N3CCC4=CC5=C(OCO5)C=C4[C@@]21[H])[C@](CCC(C)(O)C)(O)CC(OC)=O |
Synonyms | NSC 124147; NSC-124147; NSC124147; 2'R-Harringtonine; Harringtonine; Alkaloid C from cephalotaxus; |
Protocol | In Vitro | Harringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation. |
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These protocols are for reference only. InvivoChem does not
independently validate these methods.
Solvent volume to be added | Mass (the weight of a compound) | |||
---|---|---|---|---|
Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 1.8811 mL | 9.4057 mL | 18.8115 mL | 37.6230 mL |
5mM | 0.3762 mL | 1.8811 mL | 3.7623 mL | 7.5246 mL |
10mM | 0.1881 mL | 0.9406 mL | 1.8811 mL | 3.7623 mL |
20mM | 0.0941 mL | 0.4703 mL | 0.9406 mL | 1.8811 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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C1
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.