Harringtonine

This product is for research use only, not for human use. We do not sell to patients.

Harringtonine
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Size Price Stock
100mg$750Check With Us
250mg$1250Check With Us
500mg$1875Check With Us

Cat #: V20830 CAS #: 26833-85-2 Purity ≥ 98%

Description: Harringtonine is a natural Cephalotaxus alkaloid found in Cephalotaxuts.

References: Fresno M, et al. Inhibition of translation in eukaryotic systems by harringtonine. Eur J Biochem. 1977 Jan;72(2):323-30.

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Molecular Weight (MW)531.59
Molecular FormulaC28H37NO9
CAS No.26833-85-2
SMILES CodeO=C(O[C@@H]1C(OC)=C[C@]2(CCC3)N3CCC4=CC5=C(OCO5)C=C4[C@@]21[H])[C@](CCC(C)(O)C)(O)CC(OC)=O           
SynonymsNSC 124147; NSC-124147; NSC124147; 2'R-Harringtonine; Harringtonine; Alkaloid C from cephalotaxus;
ProtocolIn VitroHarringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.8811 mL9.4057 mL18.8115 mL37.6230 mL
5mM0.3762 mL1.8811 mL3.7623 mL7.5246 mL
10mM0.1881 mL0.9406 mL1.8811 mL3.7623 mL
20mM0.0941 mL0.4703 mL0.9406 mL1.8811 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.