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| Size | Price | Stock |
|---|---|---|
| 500mg | $245 | Check With Us |
| 1g | $390 | Check With Us |
| 5g | $975 | Check With Us |
: Cat #: V2088 CAS #: 78613-38-4 Purity ≥ 98%
Description: Amorolfine HCl (Ro 14-4767/002), a topically administered drug, is a potent and broad-spectrum antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts. Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation. Amorolfine is an antifungal showing activity against fungi pathogenic to plants, animals and humans. At 0.2, 2 and 5 micrograms/ml amorolfine did not have any significant inhibitory or enhancing effect on phagocytosis whether following simultaneous addition of blastospores and drug to the neutrophils, prior treatment of neutrophils for 2 h before addition of blastospores or prior treatment of blastospores for 2 h.
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- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 353.97 |
|---|---|
| Molecular Formula | C21H35NO.HCl |
| CAS No. | 78613-38-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 28 mg/mL (79.1 mM)r |
| Water: 9 mg/mL (25.4 mM)r | |
| Ethanol: 71 mg/mL (200.6 mM) | |
| SMILES Code | C[C@@H]1O[C@H](C)CN(CC(C)CC2=CC=C(C(C)(C)CC)C=C2)C1.Cl |
| Synonyms | Ro 14-4767/002; Amorolfin; Ro 14-4767-002; Ro-14-4767-002; Ro14-4767-002; Ro 14-4767; Ro-14-4767; Ro14-4767; Ro 144767; Ro-144767; Ro144767; |
| Protocol | In Vitro | Amorolfine hydrochloride acts primarily by inhibiting ergosterol biosynthesis, a component of fungal cell membrane, and possesses both fungistatic and fungicidal activity. |
|---|---|---|
| In Vivo | Amorolfine hydrochloride (0.01%-1%; Intravaginal application; twice daily for 3 days) shows anti-fungal activity in rats with vaginal candidiasis. | |
| Dosages | 0.01%-1% | |
| Administration | Intravaginal application; twice daily for 3 days |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8251 mL | 14.1255 mL | 28.2510 mL | 56.5020 mL |
| 5mM | 0.5650 mL | 2.8251 mL | 5.6502 mL | 11.3004 mL |
| 10mM | 0.2825 mL | 1.4125 mL | 2.8251 mL | 5.6502 mL |
| 20mM | 0.1413 mL | 0.7063 mL | 1.4125 mL | 2.8251 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.