SP-13786 (UAMC1110, FAP-IN-1)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1300	In Stock
500mg	$2000	In Stock
1g	$3000	In Stock

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Cat #: V4276 CAS #: 1448440-52-5 Purity ≥ 98%

Description: SP-13786 (UAMC-1110, FAP-IN-1) is a novel, potent and highly selective inhibitor of fibroblast activation protein (FAP) with IC50 of 3.2 nM; it also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM.

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Stock Solution Preparation
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Molecular Weight (MW)	344.32
Molecular Formula	C₁₇H₁₄F₂N₄O₂
CAS No.	1448440-52-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mMr
	Water: N/Ar
	Ethanol: N/A
Synonyms	SP-13786; SP13786; SP 13786; FAP-IN 1; FAP-IN-1; FAP IN 1; FAP IN-1; UAMC-1110; UAMC 1110; UAMC1110

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.9043 mL	14.5214 mL	29.0428 mL	58.0855 mL
5mM	0.5809 mL	2.9043 mL	5.8086 mL	11.6171 mL
10mM	0.2904 mL	1.4521 mL	2.9043 mL	5.8086 mL
20mM	0.1452 mL	0.7261 mL	1.4521 mL	2.9043 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.