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LSP-249

This product is for research use only, not for human use. We do not sell to patients.

LSP-249
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$1750Check With Us
1g$2650Check With Us
5g$3975Check With Us
email: [email protected]        [email protected]

Cat #: V5056 CAS #: 1801253-04-2 Purity ≥ 98%

Description: LSP-249 is a novel and potent plasma kallikrein inhibitor with a potential for treatment of angioedema.

References: Andrew Mcdonald, et al. Therapeutic inhibitory compounds. Patent. WO2016011209A1.

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Molecular Weight (MW)431.92
Molecular FormulaC24H22ClN5O
CAS No.1801253-04-2
Storage-20℃ for 3 years in powder formrr
-80℃ for 2 years in solvent
SMILES CodeO=C(C1=CC(CC2=CC=C3N=CC(Cl)=CC3=C2)=NC=C1)NCC4=C(C)C=C(N)N=C4C
SynonymsLSP-249; LSP 249; LSP249; ATN-249; ATN249; ATN 249
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3152 mL11.5762 mL23.1524 mL46.3049 mL
5mM0.4630 mL2.3152 mL4.6305 mL9.2610 mL
10mM0.2315 mL1.1576 mL2.3152 mL4.6305 mL
20mM0.1158 mL0.5788 mL1.1576 mL2.3152 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.