Alicapistat
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1850 | To Be Confirmed |
| 200mg | $2775 | To Be Confirmed |
| 500mg | $4680 | To Be Confirmed |
: Cat #: V4408 CAS #: 1254698-46-8 Purity ≥ 98%
Description: Alicapistat (also known as ABT957; ABT-957) is a novel, potent, selective and orally bioactive inhibitor of human calpains 1 and 2 whose overactivation has been linked to Alzheimer disease (AD).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 433.50 |
|---|---|
| Molecular Formula | C25H27N3O4 |
| CAS No. | 1254698-46-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C([C@@H](CC1)N(CC2=CC=CC=C2)C1=O)NC(C(C(NC3CC3)=O)=O)CC4=CC=CC=C4 |
| Synonyms | ABT-957; ABT 957; ABT957; Alicapista |
| Protocol | In Vitro | Alicapistat exihibits inadequate CNS-penetration concentrations to obtain a pharmacodynamic effect. |
|---|---|---|
| In Vivo | Alicapistat (compound 22) (iv or po; 1-3 mg/kg) shows moderate mean plasma clearance values (CLp) in mouse, rat, and dog (0.13-1.04 L/hr.kg), while high in monkey (1.98 L/hr.kg). Mean steady-state volume of distribution values (Vss) were moderate in mouse, dog, and monkey (0.64-1.8 L/kg), but higher in rat (3.4 L/kg). The plasma elimination half-life (t1/2) was shortest in dog (1.7 hours), followed by 2.3 hours in monkey and approximately 6.0 hours in mouse and rat. Oral bioavailability (F) values were high in mouse, rat, and dog (>80%), while moderate in monkey (14%). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3068 mL | 11.5340 mL | 23.0681 mL | 46.1361 mL |
| 5mM | 0.4614 mL | 2.3068 mL | 4.6136 mL | 9.2272 mL |
| 10mM | 0.2307 mL | 1.1534 mL | 2.3068 mL | 4.6136 mL |
| 20mM | 0.1153 mL | 0.5767 mL | 1.1534 mL | 2.3068 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.