RAMB4
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1100 | To Be Confirmed |
| 1g | $1750 | To Be Confirmed |
| 5g | $4430 | To Be Confirmed |
: Cat #: V2175 CAS #: 145888-79-5 Purity ≥ 98%
Description: RAMB4 (PTP1B-IN-9) is a novel and potent ubiquitin-proteasome system (UPS)-stressor.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 413.12 |
|---|---|
| Molecular Formula | C19H13Cl4NO |
| CAS No. | 145888-79-5 |
| SMILES Code | O=C1/C(CNC/C1=CC2=CC=C(Cl)C(Cl)=C2)=C/C3=CC=C(Cl)C(Cl)=C3 |
| Synonyms | PTP1B-IN-9; PTP1B-IN 9; PTP1B-IN9; RAMB4; RAMB-4; RAMB 4; |
| Protocol | In Vitro | RAMB4 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 µM. RAMB4 (0-30 µM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4206 mL | 12.1030 mL | 24.2060 mL | 48.4121 mL |
| 5mM | 0.4841 mL | 2.4206 mL | 4.8412 mL | 9.6824 mL |
| 10mM | 0.2421 mL | 1.2103 mL | 2.4206 mL | 4.8412 mL |
| 20mM | 0.1210 mL | 0.6052 mL | 1.2103 mL | 2.4206 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.