LY-345899
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1800 | Check With Us |
| 250mg | $2800 | Check With Us |
| 500mg | $4200 | Check With Us |
: Cat #: V4845 CAS #: 10538-99-5 Purity ≥ 98%
Description: LY345899 is a novel, potent inhibitor of cytoplasmic and mitochondrial methylenetetrahydrofolate dehydrogenase MTHFD1 and MTHFD2 inhibitor with a Ki of 0.018 μM.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 471.42 |
|---|---|
| Molecular Formula | C20H21N7O7 |
| CAS No. | 10538-99-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N2C(N3C4=C(O)N=C(N)N=C4NCC3C2)=O)C=C1)=O |
| Synonyms | LY345899; LY-345899; LY 345899; |
| Protocol | In Vitro | LY 345899 could suppress the MTHFD enzyme in the cytoplasm and mitochondria. |
|---|---|---|
| In Vivo | LY345899 (Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks) shows potent antitumor activity and displays therapeutic activity against CRC in vivo. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1213 mL | 10.6063 mL | 21.2125 mL | 42.4250 mL |
| 5mM | 0.4243 mL | 2.1213 mL | 4.2425 mL | 8.4850 mL |
| 10mM | 0.2121 mL | 1.0606 mL | 2.1213 mL | 4.2425 mL |
| 20mM | 0.1061 mL | 0.5303 mL | 1.0606 mL | 2.1213 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.