PF-06471553
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 100mg | $2625 | Check With Us |
| 200mg | $3935 | Check With Us |
| 500mg | $6645 | Check With Us |
: Cat #: V4472 CAS #: 1808094-07-6 Purity ≥ 98%
Description: PF-06471553 (PF06471553) is a novel, potent, selective and orally bioavailable monoacylglycerol acyltransferase 3 (MGAT3) inhibitor with the potential to treat insulin resistance, diabetes, dyslipidemia, and hepatic steatosis.
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| Molecular Weight (MW) | 467.54 |
|---|---|
| Molecular Formula | C23H25N5O4S |
| CAS No. | 1808094-07-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=S(C1=CC2=C(CN(C(CC3=CC=CC(OC)=C3)=O)C2)C=C1)(NC4=NN(C5CCC5)N=C4)=O |
| Synonyms | PF-6471553; PF 6471553; PF6471553; PF-06471553; PF 06471553; PF06471553; |
| Protocol | In Vitro | PF-06471553 (6f) is a potent and selective monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM, and shows >160 fold in vitro selectivity for MGAT3 over DGAT1 (IC50, >50 μM), DGAT2 (IC50, >100 μM), MGAT1 (IC50, 14.9 μM), and MGAT2 (IC50, 19.8 μM). PF-06471553 exhibits inhibitory activity against MGAT3 in HEK-293 cells with an IC50 of 205 nM (pIC50, 6.69). |
|---|---|---|
| In Vivo | PF-06471553 (200 mg/kg, p.o.) in addition with (DGAT1 and DGAT2) inhibitors shows additional inhibition of glycerol-d5 incorporated triolein in hMGAT3 mice, and with no effect on WT mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1389 mL | 10.6943 mL | 21.3885 mL | 42.7771 mL |
| 5mM | 0.4278 mL | 2.1389 mL | 4.2777 mL | 8.5554 mL |
| 10mM | 0.2139 mL | 1.0694 mL | 2.1389 mL | 4.2777 mL |
| 20mM | 0.1069 mL | 0.5347 mL | 1.0694 mL | 2.1389 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.