T0901317 (T-1317)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$250	Check With Us
500mg	$480	Check With Us
1g	$720	Check With Us

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Cat #: V1853 CAS #: 293754-55-9 Purity ≥ 98%

Description: T0901317 (formerly known as T-1317 or TO-091317 or TO 901317) is a potent and selective liver X receptor (LXR) agonist for multiple targets, which has EC50 values of 20 nM and 5 μM for LXRα and FXR, respectively.

References: J R Schultz, et al. Role of LXRs in Control of Lipogenesis. Genes Dev. 2000 Nov 15;14(22):2831-8.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	481.33
Molecular Formula	C17H12F9NO3S
CAS No.	293754-55-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 96 mg/mL (199.4 mM)r
	Water: <1 mg/mLr
	Ethanol: 96 mg/mL (199.4 mM)
SMILES Code	OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(N(CC(F)(F)F)S(C2=CC=CC=C2)(=O)=O)C=C1
Synonyms	TO-91317; TO 901317; TO 901317; TO-091317; TO 091317; TO091317; T-0901317; T0901317; T 0901317; T-1317; T1317; T 1317;

Protocol	In Vitro	T0901317 (5-50 μM; 72 hours) significantly inhibits cellular proliferation in CaOV3, SKOV3, A2780 (human ovarian carcinoma cell lines) in a dose-dependent and time-dependent manner.
Protocol	In Vivo	T0901317 (10 mg/kg/day; orally; for 12 weeks) inhibits the progression of atherosclerosis.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0776 mL	10.3879 mL	20.7758 mL	41.5515 mL
5mM	0.4155 mL	2.0776 mL	4.1552 mL	8.3103 mL
10mM	0.2078 mL	1.0388 mL	2.0776 mL	4.1552 mL
20mM	0.1039 mL	0.5194 mL	1.0388 mL	2.0776 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.