AR-9281
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $625 | Check With Us |
| 250mg | $990 | Check With Us |
| 500mg | $1485 | Check With Us |
: Cat #: V11535 CAS #: 913548-29-5 Purity ≥ 99%
Description: AR-9281 is a novel and potent inhibitor of soluble epoxide hydrolase (s-EH) that can be potentially used for the treatment of hypertension and type 2 diabetes.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
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| Molecular Weight (MW) | 319.44 |
|---|---|
| Molecular Formula | C18H29N3O2 |
| CAS No. | 913548-29-5 |
| SMILES Code | CC(=O)N1CCC(CC1)NC(=O)NC23CC4CC(CC(C4)C2)C3 |
| Synonyms | AR-9281; AR 9281; AR9281; Apau (enzyme inhibitor); |
| Protocol | In Vitro | AR-9281 (APAU) has inhibitory activity for human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. |
|---|---|---|
| In Vivo | AR-9281 (APAU) (oral, 150-200 mg/dL, for 6 weeks) enhances the therapeutic effects of EETs, slows progression of hyperglycemia, protects the myocyte structure, and reduces Ca2+ dysregulation and SERCA remodeling in hyperglycemic rats. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1305 mL | 15.6524 mL | 31.3048 mL | 62.6096 mL |
| 5mM | 0.6261 mL | 3.1305 mL | 6.2610 mL | 12.5219 mL |
| 10mM | 0.3130 mL | 1.5652 mL | 3.1305 mL | 6.2610 mL |
| 20mM | 0.1565 mL | 0.7826 mL | 1.5652 mL | 3.1305 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.