Zopolrestat
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $550 | To Be Confirmed |
| 250mg | $950 | To Be Confirmed |
| 500mg | $1425 | To Be Confirmed |
: Cat #: V28535 CAS #: 110703-94-1 Purity ≥ 99%
Description: Zopolrestat (CP-73850; CP73850) is a novel and potent aldose reductase inhibitor (IC50 = 3.1 nM) with the potential for the treatment of diabetic nephropathy and diabetes.
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| Molecular Weight (MW) | 419.38 |
|---|---|
| Molecular Formula | C19H12F3N3O3S |
| CAS No. | 110703-94-1 |
| SMILES Code | O=C(O)CC1=NN(CC2=NC3=CC(C(F)(F)F)=CC=C3S2)C(C4=C1C=CC=C4)=O |
| Synonyms | CP 73850; CP73850; CP-73850; Zopolrestat; Zopolrestatum |
| Protocol | In Vitro | Zopolrestat is a potent inhibitor of the reduction of both glyceraldehyde and glucose by the human and rat enzymes. |
|---|---|---|
| In Vivo | Zopolrestat (2.5 mg/kg-50 mg/kg; p.o.; once-a-day for 5 days) and left untreated for 7 days) prevents accumulation of sorbitol in the kidney cortex of diabetic rats and normalize elevated renal blood flow in galactosemic rats. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3845 mL | 11.9224 mL | 23.8447 mL | 47.6894 mL |
| 5mM | 0.4769 mL | 2.3845 mL | 4.7689 mL | 9.5379 mL |
| 10mM | 0.2384 mL | 1.1922 mL | 2.3845 mL | 4.7689 mL |
| 20mM | 0.1192 mL | 0.5961 mL | 1.1922 mL | 2.3845 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.