Home > Signaling Pathways>Metabolic Enzyme/Protease>Aldose Reductase>Lidorestat
Lidorestat

This product is for research use only, not for human use. We do not sell to patients.

Lidorestat
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$900To Be Confirmed
1g$1550To Be Confirmed
5g$3925To Be Confirmed
email: [email protected]        [email protected]

Cat #: V24126 CAS #: 245116-90-9 Purity ≥ 99%

Description: Lidorestat (EML-676; ALN-101; IDD-000676-01; IDD-676) is a novel and potent aldose reductase inhibitor which is orally bioactive and can be used to treat chronic diabetes complications. It inhibits aldose reductase with an IC50 of 5 nM.

References: Noh HL, et al. Regulation of plasma fructose and mortality in mice by the aldose reductase inhibitor lidorestat. J Pharmacol Exp Ther. 2009 Feb;328(2):496-503.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)376.35
Molecular FormulaC18H11F3N2O2S
CAS No.245116-90-9
SMILES CodeO=C(O)CN1C=C(CC2=NC3=C(F)C(F)=CC(F)=C3S2)C4=C1C=CC=C4
SynonymsEML 676; IDD 676; IDD 000676 01; IDD 00067601; ALN-101; EML-676; IDD-676; IDD-000676-01; IDD-00067601; ALN101; EML676; IDD676; IDD00067601; IDD00067601; ALN 101;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6571 mL13.2855 mL26.5710 mL53.1420 mL
5mM0.5314 mL2.6571 mL5.3142 mL10.6284 mL
10mM0.2657 mL1.3286 mL2.6571 mL5.3142 mL
20mM0.1329 mL0.6643 mL1.3286 mL2.6571 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.