XMD8-87 (ACK1-B19)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1495 | Check With Us |
| 500mg | $2390 | Check With Us |
| 1g | $3585 | Check With Us |
: Cat #: V2593 CAS #: 1234480-46-6 Purity ≥ 98%
Description: XMD8-87 (also known as ACK1-B19) is a novel tyrosine kinase nonreceptor 2(TNK2) inhibitor with IC50s of 38 nmol/L and 113 nmol/L for the D163E and R806Q mutations.
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| Molecular Weight (MW) | 445.52 |
|---|---|
| Molecular Formula | C24H27N7O2 |
| CAS No. | 1234480-46-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 65 mg/mL (145.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 10 mg/mL (22.4 mM) | |
| SMILES Code | C1=NC(NC2=CC=C(N3CCN(C)CC3)C=C2OC)=NC2N(C)C3C=CC=CC=3C(=O)NC1=2 |
| Synonyms | ACK1-B19; ACK1 B19; ACK1B19; XMD8-87; XMD-8-87; XMD 8-87; XMD887; XMD-887; XMD 887; |
| Protocol | In Vitro | XMD8-87 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD8-87 has IC50s of 38 nM and 113 nM for the D163E and R806Q mutations. The effects of XMD8-87 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD8-87. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2446 mL | 11.2228 mL | 22.4457 mL | 44.8914 mL |
| 5mM | 0.4489 mL | 2.2446 mL | 4.4891 mL | 8.9783 mL |
| 10mM | 0.2245 mL | 1.1223 mL | 2.2446 mL | 4.4891 mL |
| 20mM | 0.1122 mL | 0.5611 mL | 1.1223 mL | 2.2446 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.