ZAP-180013

This product is for research use only, not for human use. We do not sell to patients.

ZAP-180013
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1250Check With Us
200mg$1875Check With Us
500mg$3165Check With Us

Cat #: V40972 CAS #: 873080-25-2 Purity ≥ 99%

Description: ZAP-180013 is a novel and potent inhibitor of zeta-chain-associated protein kinase 70 (ZAP-70) with an IC50 of 1.8 μM.

References: Patrick R Visperas, et al. Identification of Inhibitors of the Association of ZAP-70 With the T Cell Receptor by High-Throughput Screen. SLAS Discov. 2017 Mar;22(3):324-331.

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Molecular Weight (MW)454.33
Molecular FormulaC19H17Cl2N3O4S
CAS No.873080-25-2
SMILES CodeO=C(C1=NC(S(=O)(CC)=O)=NC=C1Cl)N(CC2=CC=C(Cl)C=C2)CC3=CC=CO3           
SynonymsZAP 180013; ZAP180013; ZAP-180013
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2010 mL11.0052 mL22.0104 mL44.0209 mL
5mM0.4402 mL2.2010 mL4.4021 mL8.8042 mL
10mM0.2201 mL1.1005 mL2.2010 mL4.4021 mL
20mM0.1101 mL0.5503 mL1.1005 mL2.2010 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.