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KML-29

This product is for research use only, not for human use. We do not sell to patients.

KML-29
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$1550To Be Confirmed
1g$2150To Be Confirmed
5g$5440To Be Confirmed
email: [email protected]        [email protected]

Cat #: V12562 CAS #: 1380424-42-9 Purity ≥ 98%

Description: KML-29 is monoacylglycerol lipase inhibitor and an O-hexafluoroisopropyl carbamate analogue of JZL 184.

References: Natsuo Ueda, et al. Discrimination between two endocannabinoids. Chem Biol. 2012 May 25;19(5):545-7.

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Molecular Weight (MW)549.42
Molecular FormulaC24H21F6NO7
CAS No.1380424-42-9
SMILES CodeO=C(N1CCC(C(C2=CC=C(OCO3)C3=C2)(C4=CC=C(OCO5)C5=C4)O)CC1)OC(C(F)(F)F)C(F)(F)F
SynonymsKML-29; KML29; KML 29
ProtocolIn VitroKML29 dose-dependently elevates brain 2-AG level up to 10-fold without alteration in brain levels of anandamide, palmitoylethanolamide, and oleoylethanolamide.
In VivoKML29 enhibits antinociceptive activity without cannabimimetic side effects.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.8201 mL9.1005 mL18.2010 mL36.4020 mL
5mM0.3640 mL1.8201 mL3.6402 mL7.2804 mL
10mM0.1820 mL0.9101 mL1.8201 mL3.6402 mL
20mM0.0910 mL0.4550 mL0.9101 mL1.8201 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.