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PF-06747711

This product is for research use only, not for human use. We do not sell to patients.

PF-06747711
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$850Check With Us
250mg$1800Check With Us
500mg$2700Check With Us
email: [email protected]        [email protected]

Cat #: V4466 CAS #: 1892576-58-7 Purity ≥ 98%

Description: PF-06747711 (PF06747711) is a novel, potent, selective, and orally bioactive retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist with anti-skin inflammatory activity.

References: Schnute ME, et al. Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agoni

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Molecular Weight (MW)497.51
Molecular FormulaC26H26F3N5O2
CAS No.1892576-58-7
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeO=C(NC1=CN=C(N(C)C=C2C3CCN(C(C(C)C)=O)CC3)C2=C1C(F)(F)F)C4=CC=CC(C#N)=C4
SynonymsPF-06747711; PF 06747711; PF06747711; RORC2 Inverse Agonist;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.0100 mL10.0500 mL20.1001 mL40.2002 mL
5mM0.4020 mL2.0100 mL4.0200 mL8.0400 mL
10mM0.2010 mL1.0050 mL2.0100 mL4.0200 mL
20mM0.1005 mL0.5025 mL1.0050 mL2.0100 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Volume(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.