CD437
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $700 | Check With Us |
| 250mg | $1300 | Check With Us |
| 500mg | $1950 | Check With Us |
: Cat #: V17767 CAS #: 125316-60-1 Purity ≥ 99%
Description: CD437 is a novel and potent RARγ agonist.
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| Molecular Weight (MW) | 398.49 |
|---|---|
| Molecular Formula | C27H26O3 |
| CAS No. | 125316-60-1 |
| SMILES Code | O=C(C1=CC=C2C=C(C3=CC=C(O)C(C45CC6CC(C5)CC(C6)C4)=C3)C=CC2=C1)O |
| Synonyms | CD437; CD 437; CD-437; Ro-472077; Ro 472077; Ro472077; AHPN |
| Protocol | In Vitro | CD437 is a selective RARγ agonist. Growth inhibition by CD437 in these lung cancer cell lines is apparent after 2 days of treatment with 10 μM CD437. Dose-response experiments demonstrate that CD437 reduces the numbers of H460, SK-MES-1, A549, and H292 cells with 50% inhibitory values of approximately 0.5, 0.4, 3, and 0.85 μM, respectively. |
|---|---|---|
| In Vivo | Tumors in CD437-treated mice stop growing, an effect that becomes already statistically significant (P<0.01) at day 13, 3 d after first administration of CD437, and is maintained for more than 3 wk after discontinuation of treatment. Further histologic analysis demonstrates marked c-fos mRNA levels at the tumor-stroma edge in CD437-treated tumors. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5095 mL | 12.5474 mL | 25.0947 mL | 50.1895 mL |
| 5mM | 0.5019 mL | 2.5095 mL | 5.0189 mL | 10.0379 mL |
| 10mM | 0.2509 mL | 1.2547 mL | 2.5095 mL | 5.0189 mL |
| 20mM | 0.1255 mL | 0.6274 mL | 1.2547 mL | 2.5095 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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Concentration(final)
C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.