LY-2955303
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1650 | Check With Us |
| 250mg | $2650 | Check With Us |
| 1g | $3975 | Check With Us |
: Cat #: V2132 CAS #: 1433497-19-8 Purity ≥ 98%
Description: LY2955303 (LY-2955303) is a novel, potent and selective antagonist of retinoic acid receptor gamma (RARγ) with potential to manage osteoarthritis pain.
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| Molecular Weight (MW) | 578.74 |
|---|---|
| Molecular Formula | C36H42N4O3 |
| CAS No. | 1433497-19-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(O)C1=CC=C(C2=NN(C3=CC=C(C(N4CCN(C)CC4)=O)C=C3)C(C5=CC(C(C)(C)C)=CC(C(C)(C)C)=C5)=C2)C=C1 |
| Synonyms | LY2955303; LY-2955303; LY 2955303 |
| Protocol | In Vitro | LY2955303 is tested and observed that the binding Kis for RARα, RARβ and RARγ are >1700, >2980 and 1.09 nM, respectively. The functional Ki for RARγ is 7.1±4.9 nM. |
|---|---|---|
| In Vivo | A single oral dose of LY2955303 demonstrates a dose responsive effect whereby the rat reduces differential weight bearing (ED50=0.72 mg/kg). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7279 mL | 8.6395 mL | 17.2789 mL | 34.5578 mL |
| 5mM | 0.3456 mL | 1.7279 mL | 3.4558 mL | 6.9116 mL |
| 10mM | 0.1728 mL | 0.8639 mL | 1.7279 mL | 3.4558 mL |
| 20mM | 0.0864 mL | 0.4320 mL | 0.8639 mL | 1.7279 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.