PACMA 31
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $950 | To Be Confirmed |
| 250mg | $1550 | To Be Confirmed |
| 500mg | $2325 | To Be Confirmed |
: Cat #: V27064 CAS #: 1401089-31-3 Purity ≥ 99%
Description: PACMA 31 (PACMA31; PACMA-31) is a novel, orally bioavailable, and covalent/irreversible inhibitor of protein disulfide isomerase (PDI) with potentian anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 430.47 |
|---|---|
| Molecular Formula | C21H22N2O6S |
| CAS No. | 1401089-31-3 |
| SMILES Code | O=C(OCC)CNC(C(C1=CC=CS1)N(C2=CC=C(OC)C=C2OC)C(C#C)=O)=O |
| Synonyms | PACMA 31; PACMA31; PACMA-31; |
| Protocol | In Vitro | PACMA 31 (0-10 μM; 24 hours) significantly inhibits colony formation in OVCAR-8 cells in a dose-dependent manner. |
|---|---|---|
| In Vivo | PACMA 31 (20-200 mg/kg; i.p.; daily for 62 days) suppresses tumor growth in human ovarian cancer mouse xenografts. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3230 mL | 11.6152 mL | 23.2304 mL | 46.4608 mL |
| 5mM | 0.4646 mL | 2.3230 mL | 4.6461 mL | 9.2922 mL |
| 10mM | 0.2323 mL | 1.1615 mL | 2.3230 mL | 4.6461 mL |
| 20mM | 0.1162 mL | 0.5808 mL | 1.1615 mL | 2.3230 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.