GW280264X
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $3150 | Check With Us |
| 200mg | $4725 | Check With Us |
| 500mg | $7970 | Check With Us |
: Cat #: V2172 CAS #: 866924-39-2 Purity ≥ 98%
Description: GW280264X is a novel and potent ADAM17 inhibitor.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 575.72 |
|---|---|
| Molecular Formula | C28H41N5O6S |
| CAS No. | 866924-39-2 |
| SMILES Code | O=C(OCC1=CC=CC=C1)NCCCC[C@H](NC([C@H](CC(C)C)[C@@H](N(C=O)O)CCC)=O)C(NC2=NC=CS2)=O |
| Synonyms | GW280264X; GW-280264X; GW 280264X; GW280264; GW-280264; GW 280264 |
| Protocol | In Vitro | The proliferation of GS-7 cells was significantly reduced upon treatment with GW280264X or ADAM10/17 co-knockdown. |
|---|---|---|
| In Vivo | Pharmacological inhibition of ADAM10 and ADAM17 improves functional recovery after spinal cord injury (SCI). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7370 mL | 8.6848 mL | 17.3696 mL | 34.7391 mL |
| 5mM | 0.3474 mL | 1.7370 mL | 3.4739 mL | 6.9478 mL |
| 10mM | 0.1737 mL | 0.8685 mL | 1.7370 mL | 3.4739 mL |
| 20mM | 0.0868 mL | 0.4342 mL | 0.8685 mL | 1.7370 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.