Enarodustat (JTZ951)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $605 | Check With Us |
| 250mg | $1105 | Check With Us |
| 500mg | $1655 | Check With Us |
: Cat #: V20522 CAS #: 1262132-81-9 Purity ≥ 98%
Description: Enarodustat (formerly JTZ-951; JTZ951; Enaroy) is an orally bioactive hypoxia inducible factor-proly hydroxylase (HIF-PH) inhibitor approved (in 2020) in Japan for the treatment of anemia associated with chronic kidney disease (CKD).
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| Molecular Weight (MW) | 340.33 |
|---|---|
| Molecular Formula | C17H16N4O4 |
| CAS No. | 1262132-81-9 |
| SMILES Code | O=C(O)CNC(C1=C(O)C=C(CCC2=CC=CC=C2)N3C1=NC=N3)=O |
| Synonyms | Enarodustat; JTZ-951; JTZ 951; JTZ951; |
| Protocol | In Vitro | Enarodustat (JTZ-951) is a potent and orally active hypoxia-inducible factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition. |
|---|---|---|
| In Vivo | Enarodustat (1 and 3 mg/kg, p.o.) increases hemoglobin levels in a dose-dependent manner with daily oral dosing in rats. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9383 mL | 14.6916 mL | 29.3832 mL | 58.7665 mL |
| 5mM | 0.5877 mL | 2.9383 mL | 5.8766 mL | 11.7533 mL |
| 10mM | 0.2938 mL | 1.4692 mL | 2.9383 mL | 5.8766 mL |
| 20mM | 0.1469 mL | 0.7346 mL | 1.4692 mL | 2.9383 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.