Amifostine trihydrate (WR2721)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $245 | Check With Us |
| 10g | $845 | Check With Us |
| 20g | $1265 | Check With Us |
: Cat #: V1909 CAS #: 112901-68-5 Purity ≥ 98%
Description: Amifostine trihydrate (WR2721), a phosphorylated aminosulfhydryl compound, is the first approved radioprotective drug, it is used to decrease the risk of kidney problems caused by treatment with cisplatin.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 268.27 |
|---|---|
| Molecular Formula | C5H15N2O3PS.3H2O |
| CAS No. | 112901-68-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: <1 mg/mLr |
| Water: 42 mg/mL (156.55 mM)r | |
| Ethanol: <1 mg/mL | |
| SMILES Code | OP(O)(SCCNCCCN)=O.[H]O[H].[H]O[H].[H]O[H] |
| Synonyms | YM08310; YM-08310; YM 08310; WR2721; WR-2721; WR 2721; ethiofos; gammaphos; Ethyol; APAETP; Aminopropylaminoethylthiophosphoric Acid; |
| Protocol | In Vitro | Amifostine (0.78125-100 μM, 24 h) trihydrate reduces tert-Butyl hydroperoxide (TBHP)-induced cell damage in a dose-dependent manner and significantly reduces H9c2 cells apoptosis at a concentration of 100 μM. |
|---|---|---|
| In Vivo | Amifostine (i.v., 400 mg/kg, 4 h) trihydrate has a protective effect against myocardial I/R injury in male C57BL/6 mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7276 mL | 18.6379 mL | 37.2759 mL | 74.5518 mL |
| 5mM | 0.7455 mL | 3.7276 mL | 7.4552 mL | 14.9104 mL |
| 10mM | 0.3728 mL | 1.8638 mL | 3.7276 mL | 7.4552 mL |
| 20mM | 0.1864 mL | 0.9319 mL | 1.8638 mL | 3.7276 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.