Sitagliptin phosphate

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
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25g	$1000	Check With Us
50g	$1500	Check With Us

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Cat #: V29755 CAS #: 654671-78-0 Purity ≥ 99%

Description: Sitagliptin phosphate (MK431; Januvia), the phosphate salt of Sitagliptin, is an antihyperglycemic agent (sugar-lowering) and antidiabetic medication that act as a potent inhibitor of DPP-IV (dipeptidyl peptidase-4) with IC50 of 19 nM in Caco-2 cell extracts.

References: Thomas, L., et al. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylm ethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of acti

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Molecular Weight (MW)	505.31
Molecular Formula	C16H18F6N5O5P
CAS No.	654671-78-0
SMILES Code	O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O)(O)
Synonyms	Sitagliptin phosphate; Sitagliptin; LEZ 763; LEZ-763; LEZ763; MK0431; MK 0431; MK-0431;

Protocol	In Vitro	Sitagliptin phosphate exhibits a potent inhibitory effect on DPP-4 with IC50 of 19 nM from Caco-2 cell extracts.
Protocol	In Vivo	In vivo, the ED50 value of sitagliptin phosphate for inhibition of plasma DPP-4 activity is calculated to be 2.3 mg/kg 7 hour postdose and 30 mg/kg 24 hour postdose in freely fed Han-Wistar rats.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9790 mL	9.8949 mL	19.7898 mL	39.5797 mL
5mM	0.3958 mL	1.9790 mL	3.9580 mL	7.9159 mL
10mM	0.1979 mL	0.9895 mL	1.9790 mL	3.9580 mL
20mM	0.0989 mL	0.4947 mL	0.9895 mL	1.9790 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.