Fomepizole | CAS 7554-65-6

Fomepizole

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
5g	$150	Check With Us
10g	$250	Check With Us
20g	$375	Check With Us

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Cat #: V2677 CAS #: 7554-65-6 Purity ≥ 98%

Description: Fomepizole (also known as 4-methylpyrazole, Antizol, Antizol-Vet) is a competitive inhibitor of alcohol dehydrogenase, an enzyme that catalyzes the initial steps in the metabolism of ethylene glycol,ethanol and methanol to their toxic metabolites.

References: Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	82.1
Molecular Formula	C4H6N2
CAS No.	7554-65-6
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: N/Ar
	Water: 146 mg/mLr
	Ethanol: N/A
SMILES Code	CC1=CNN=C1
Synonyms	4-methylpyrazole, Antizol; Fomepizole; Fomepizolum

Protocol	In Vitro	Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	12.1803 mL	60.9013 mL	121.8027 mL	243.6054 mL
5mM	2.4361 mL	12.1803 mL	24.3605 mL	48.7211 mL
10mM	1.2180 mL	6.0901 mL	12.1803 mL	24.3605 mL
20mM	0.6090 mL	3.0451 mL	6.0901 mL	12.1803 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.