CAY10650
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1650 | Check With Us |
| 250mg | $2950 | Check With Us |
| 500mg | $4425 | Check With Us |
: Cat #: V2928 CAS #: 1233706-88-1 Purity ≥ 98%
Description: CAY10650 (CAY-10650) is a novel and highly potent inhibitor of cytosolic phospholipase A2α (cPLA2α) (IC50 = 12 nM) with anti-inflammatory activity.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 471.5 |
|---|---|
| Molecular Formula | C28H25NO6 |
| CAS No. | 1233706-88-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 43 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: NA | |
| SMILES Code | O=C(C1=CC2=C(N(CC(COC3=CC=C(OC4=CC=CC=C4)C=C3)=O)C=C2C(C(C)C)=O)C=C1)O |
| Synonyms | CAY-10650; CAY10650; CAY 10650 |
| Protocol | In Vitro | CAY10650 (12 nM; 2 h; neutrophils) inhibits PGE2 release in neutrophils. CAY10650 (12 nM; 30 min; neutrophils) inhibits the expression of the phosphorylated cPLA2-α (p-cPLA2-α) in cells. |
|---|---|---|
| In Vivo | CAY10650 (50 μg/5 μL; Inject with topical eye-drop; Chinese hamsters) relieves acanthamoeba keratitis in vivo. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1209 mL | 10.6045 mL | 21.2089 mL | 42.4178 mL |
| 5mM | 0.4242 mL | 2.1209 mL | 4.2418 mL | 8.4836 mL |
| 10mM | 0.2121 mL | 1.0604 mL | 2.1209 mL | 4.2418 mL |
| 20mM | 0.1060 mL | 0.5302 mL | 1.0604 mL | 2.1209 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.