GW4869 HCl | CAS 6823-69-4

GW4869 HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1495	Check With Us
500mg	$2242	Check With Us
1g	$3363	Check With Us

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Cat #: V2778 CAS #: 6823-69-4 Purity ≥ 98%

Description: GW4869 HCl (GW-4869; GW-69A; GW-554869A), the dihydrochloride salt of GW4869, is a neutral, cell permeable and noncompetitive inhibitor of sphingomyelinase (SMase) (IC50 = 1 μM) and is most widely used pharmacological agent for blocking exosome generation.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	577.5
Molecular Formula	C30H28N6O2.2HCl.XH2O
CAS No.	6823-69-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: < 1mg/mLr
	Water: < 1mg/mLr
	Ethanol: < 1mg/mL
SMILES Code	O=C(/C=C/C1=CC=C(C=C1)/C=C/C(NC2=CC=C(C=C2)C3=NCCN3)=O)NC4=CC=C(C=C4)C5=NCCN5.[H]Cl.[H]Cl
Synonyms	GW4869 HCl; GW69A; GW-554869A HCl; GW-4869 HCl; GW 4869 HCl; GW-69A; GW554869A HCl; GW 554869A HCl; GW 69A; GW-4869 HCl

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7316 mL	8.6580 mL	17.3160 mL	34.6320 mL
5mM	0.3463 mL	1.7316 mL	3.4632 mL	6.9264 mL
10mM	0.1732 mL	0.8658 mL	1.7316 mL	3.4632 mL
20mM	0.0866 mL	0.4329 mL	0.8658 mL	1.7316 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.